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The stage is set for a intriguing top-flight matchup as front-runners the Gunners host struggling Wolves to the Emirates Stadium.

Confirmed Sides

Arsenal have made a trio of alterations from the side that suffered a 2-1 loss at Villa Park last weekend. William Saliba, the Swedish striker and Gabriel Martinelli all come into the starting eleven. The captain and Mikel Merino are named on the bench, while Riccardo Calafiori is not involved. Saliba returns after sitting out five matches due to injury.

The visitors also make three adjustments to their lineup following being soundly beaten 4-1 at home by United on Monday evening. Matt Doherty, João Gomes and the South Korean forward start. Ki-Jana Hoever and Jhon Arias drop to the bench, while Jean‐Ricner Bellegarde is not in the squad altogether.

Confirmed Lineups

Arsenal: Raya, White, Saliba, Hincapie, Timber, Eze, Zubimendi, Rice, Saka, Gyokeres, Martinelli.
Bench: Arrizabalaga, Odegaard, Gabriel Jesus, Norgaard, Trossard, Madueke, Nwaneri, Merino, Lewis-Skelly.

Wolverhampton Wanderers: Johnstone, Mosquera, Agbadou, Toti Gomes, Doherty, Joao Gomes, Andre Trindade, Krejci, Wolfe, Larsen, Hwang.
Subs: Tchatchoua, Mane, Lopez, Hoever, Chirewa, Arokodare, Arias, Santiago Bueno, Jose Sa.

Referee: Robert Jones
Video Assistant Referee: John Brooks

Preamble

Good evening! Because, look at this …

The standings tells a clear contrast. The hosts sit proudly at the pinnacle of the Premier League, while Wolves prop up the division.

… yet while this will be the 42nd occasion the Premier League leaders have played the team at the foot of the division – winning 30 out of 41, with seven tied games – which team is responsible for two of the four all-time upsets? Why, Wolves, of course! Therefore, although the Arsenal manager will undoubtedly be expecting another victory, the Wolves boss must know that underdogs occasionally find the target, and you never know. The start is at 8pm GMT. Let's go!

^{(The other two last-over-first victories in the Premier League era are Oldham Athletic's 1-0 win over United in March 1993, and Tottenham Hotspur – admittedly, this one sounds a bit weird - beating Liverpool in November 2008.)}